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While the exact causes of these erythrocyte changes are due to fibrin amyloid microclots or other factors, such as ROS (which can cause RBC changes as well [367, 368]), remain unclear, they likely contribute to the oxidative stress observed in Long COVID [369, 370]

Upon binding of a second equivalent of GSH into a highly energetic intermediate, the oxidized product GSSG is formed, and a ruthenium diamine complex generated

GGT activity (d) (n = 6 technical replicates from 3 independent experiments) and cell numbers (e) (n = 3 technical replicates for Cys 2 -free or n = 6 technical replicates for Control or Cys 2 -free + GSH from 3 independent experiments) for cells grown in control (208 M cystine

Pierre Goussard F, Retief J, Burke, et al